Scientific Research Paper

Use of genetic engineering in fungi for the production of L-dopa The biochemistry of L-dopa synthesis in fungi is a complex and fascinating topic that has been the subject of much research in recent years. L-dopa , also known as levodopa, is an important neurotransmitter and precursor to the neurotransmitter dopamine . It is used clinically as a treatment for Parkinson's disease, a degenerative disorder of the nervous system characterized by tremors, stiffness, and difficulty with movement. The first step in the synthesis of L-dopa in fungi is the conversion of tyrosine to L-tyrosine by the enzyme tyrosine hydroxylase . This reaction requires the cofactor tetrahydrobiopterin and requires oxygen and iron. L-tyrosine is then converted to L-dopa by the enzyme tyrosinase. This reaction requires copper and oxygen. L-dopa production by using fungi The enzymes involved in L-dopa synthesis in fungi are regulated by a variety of factors. Tyrosine hydroxylase activity is regulated by t...